Human Genetics Unit

Mohammad Reza Abbaszadegan

   

Professor of Human Genetics 

https://isid.research.ac.ir/MohammadReza_Abbaszadegan

Head:Dr. Mohammad Reza Abbasszadegan, PhD in Genetics

Full Professor

Activities:

  • Evaluation of Novel Molecular tumor markers for early diagnostic and prognostic purpostic in GI. Cancers
  • Establishment of cell line for esophageal squamous cell carcinoma (ESCC) and gastric cancer
  • ESCC and gastric cancer mRNA transfer in dendritic cells and immuno-gene therapy of ESCC cancer
  • Molecular characterization of mutant genes in Genetic diseases (i.e. Congenital Adrenal Hyperplasia)
  • CRISPR/Cas9 based gene editing in Hematopoietic stem cell isolated from beta- thalassemia patient
  • Identification of potentially pathogenic and prognostic genes and pathways associated with esophageal squamous cell carcinoma, gastric, and colorectal progression using RNA-seq data from GEO and TCGA databases
  • Serum extracellular vesicles (Exosome) containing non-coding RNAs serve as a potential biomarker for colorectal cancer diagnosis

Educational Activities :

Holding educational workshops such as:

  • Flow cytometry
  • Workshop for DNA and RNA extraction from different sources (e. g., blood, tissue, bone marrow, and body fluids)
  • RT-PCR and PCR workshops
  • Quantitative analysis and comparison of gene expression using the modern technique of real-time PCR
  • Introduction of basic skills in molecular genetics
  • Fundamentals of cell culture
  • Fundamentals of PCR and electrophoresis
  • Fundamentals and review of new compound proteins
  • Natural protein extraction from pollen plants and fruits